Dietary and Botanical Supplement Therapy in Diabetes

Authors

  • Shagun Bindlish, MD The Diabetes Institute at Ohio University Ohio University Heritage College of Osteopathic Medicine Athens, OH Camden Clark Medical Center, Parkersburg WV
  • Jay H. Shubrook Jr., DO, FACOFP The Diabetes Institute at Ohio University Ohio University Heritage College of Osteopathic Medicine Athens, OH

Abstract

Context: As diabetes epidemic is gaining momentum in the society, the use of complementary and alternative medicine (CAM) either in conjunction or as an alternative to conventional medicines is now common and popular. The use of CAM supplement is commonly ignored by physicians and patients with a belief that supplements are natural and not medicine. Thus, the spectrum of polypharmacy mandates clinician expertise to become well informed about the common CAM supplements used in treating diabetes.

Evidence Acquisition: An extensive literature search of clinical trials, systematic reviews, and narrative reviews was completed in PubMed from years 1970 to 2013. The keywords for this search included diabetes, complementary and alternative medicine, botanical supplements, and herbal medicine.
Evidence Synthesis: Modern societies are experiencing unprecedented levels of chronic and preventable diseases. Western medications often treat the symptoms or the effects of a disease but do little to prevent them. This issue in general has diverted people’s attention again towards dietary supplements and herbal medicine over the past few years. Therefore, the use of medicinal foods, nutritional supplements are becoming more common to prevent disease and related complications. Since there is no documentation of adverse effects, the potential for herb- drug or herb-dietary supplement interaction is a big challenge due to the multiple prescription medicines consumed by the diabetic patients. However, even though CAM therapies have been shown to have impact on the glycemic control, the risk associated with the drug use is still a concern.

Conclusion: The purpose of this clinical review is to bring awareness among health care providers about selected dietary and botanical supplements frequently used by the patients with diabetes and to provide a framework to advice patients on CAM use.

 

Author Biographies

Shagun Bindlish, MD, The Diabetes Institute at Ohio University Ohio University Heritage College of Osteopathic Medicine Athens, OH Camden Clark Medical Center, Parkersburg WV

Diabetologist

Jay H. Shubrook Jr., DO, FACOFP, The Diabetes Institute at Ohio University Ohio University Heritage College of Osteopathic Medicine Athens, OH

Diabetologist

References

Hsiao-yun Chang, Marianne Wallis, Evelin Tiralongo: Use of complementary and alternative medicine among people living with diabetes: literature review. Journal of advanced nursing. Volume 58, Issue 4, pages 307–319, May 2007

Kanadiya M, Klein G, Shubrook JH. Use of and Attitudes toward Complementary and Alternative Medicine among Osteopathic Medical Students. JAOA 2012. 112; 7:437-446.

National Center for Complementary and Alternative Medicine, National Institutes Health: What is CAM http://nccam.nih.gov/health/whatiscam/overview.htm. Accessed on October 23, 2013

Duke Integrative medicine : www.dukeintegrativemedicine.org/about-us/what-is-integrative-medicine‎ Accessed on October 23,2013

Dietary Supplementation Health and Education Act of 1994, Public Law No. 103-417

Office of dietary supplements: http://ods.od.nih.gov/factsheets/DietarySupplements-HealthProfessional/ Accessed on October 23,2013

Anderson RA: Nutritional factors influencing the glucose/insulin system: chromium. J Am Coll Nutr 1997. 16:404–410.

Ravina A, Slezak L, Rubal A, Mirsky N: Clinical use of the trace element chromium (III) in the treatment of diabetes mellitus. J Trace Elem Exp Med 1995. 8:183–190

Jovanovic L, Gutierrez M, Peterson CM: Chromium supplementation for women with gestational diabetes mellitus. J Trace Elem Exp Med 1999. 12:91–97.

Ravina A, Slezak L, Mirsky N, Bryden NA, Anderson RA: Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabetes Med 1999. 16:164–167.

Ravina A, Slezak L, Rubal A, Mirsky N: Clinical use of the trace element chromium (III) in the treatment of diabetes mellitus. J Trace Elem Exp Med 1995. 8:183–190.

Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem. 2004 May;11(9):1135-46

D Ziegler, M Hanefeld, K J Ruhnau, H Hasche, M Lobisch, Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). Alpha-Lipoic Acid in Diabetic Neuropathy. Diabetes Care 1999. 22 (8)1296-1301

Kamenova P: Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones 2006(Athens) 5:251–258.

Jellin JM,Gregory PJ,Batz F, Hitchens K,et al: Pharmacist’s letter/Prescriber’s Letter Natural Medicines Comprehensive Database.9th ed. Stockton,CA, Therapeutic Research Faculty,2007

Mooradian AD, Failla M, Hoogwerf B, Maryniuk M, Wylie-Rosett J: Selected vitamins and minerals in diabetes. Diabetes Care 17:464–479, 1994

Chopra A, Doiphode VV. Ayurvedic medicine. Core concept, therapeutic principles, and current relevance. Medical Clinics of North America. 2002;86(1):75–88.

Conboy L, Edshteyn I, Garivaltis H. Ayurveda and Panchakarma: measuring the effects of a holistic health intervention. Scientific World Journal. 2009;9: 272–280.

Kuppurajan K, Seshadri C, Revathi R, Venkataraghavah S: Hypoglycaemic effect of Coccinia indica in diabetes mellitus. Nagarjun 1986. 29:1–4.

Kuriyan R, Rajendran R, Bantwal G, Kurpad AV: Effect of supplementation of Coccinia cordifolia extract on newly detected diabetic patients. Diabetes Care 2008. 31:216–220.

Khan A, Safdar M,AliKhan MM, Khattak KN, Anderson RA : Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care December 2003 vol. 26 no. 12 3215-3218

Vanschoonbeek K, Thomassen BJ, Senden JM.Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients. J Nutr. 2006 Apr;136(4):977-980.

Blumenthal M, Busse WR, Goldberg A, et al: The Complete German Commision E Monographs: Therapeutic Guide to Herbal medicines. Klein S,trans. Boston, American Botanical council,1998

Yoo, K. M., Lee, C., Lo, Y. M. and Moon, B. The Hypoglycemic Effects of American Red Ginseng (Panax quinquefolius L.) on a Diabetic Mouse Model. Journal of Food Science 2012. 77: H147–H152.

Qi LW, Wang CZ, Du GJ, Zhang ZY, Calway T, Yuan CS.Metabolism of ginseng and its interactions Curr Drug Metab. 2011;12(9):818-822.

University of Maryland Medical Center: http://umm.edu/health/medical/altmed/herb-interaction/possible-interactions-with-asian-ginseng

Hsu CH, Liao YL, Lin SC, Hwang KC, Chou P The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med. 2007 ;13(1):97-102.

Preuss HG, Jarrell ST, Scheckenbach R, Lieberman S, Anderson RA:Comparative effects of chromium, vanadium and gymnema sylvestre on sugar-induced blood pressure elevations in SHR. J Am Coll Nutr 17:116–123, 1998

Baskaran K, KizarAhamath B, RadhaShanmugasundaram K,Shanmugasundaram E: Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990. 30:295–300.

Welhinda J, Karunanayake EH, Sheriff MHR, Jayasinghe KSA: Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacology 1986. 17:277–282.

Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, Venkaiah K: Antidiabetic and adaptogenic properties of Momordica charantia extract. Phytother Res 1993; 7:285–289.

Forinash AB, Yancey AM, Barnes KN, Myles TDThe use of galactogogues in the breastfeeding mother. Ann Pharmacother. 2012;46(10):1392-404. doi: 10.1345/aph.1R167. Epub 2012 Sep 25.

Sharma RD: Effect of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjects. Nutr Res 1986; 6:1353–1364.

Coronado GD, Thompson B, Tejeda S, Godina R: Attitudes and beliefs among Mexican Americans about type 2 diabetes. J Health Care PoorUnderserved 2004;15:576–588.

DerMarderosian A, Beutler JA (eds): The review of Natural Products. St. Louis, Mo.,Wolters Kluver Health,2006

Norlaily Mohd Ali, Swee Keong Yeap,2Wan Yong Ho, Boon Kee Beh, Sheau Wei Tan, and Soon Guan TanThe Promising Future of Chia, Salvia hispanica L. Journal of Biomedicine and Biotechnology Volume 2012 (2012), Article ID 171956 Page 1-9

Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V,: Antidiabetic activity of aloe vera L. juice. II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomed 1996. 3:245–248.

The H.E.R.B.A.L guide Dietary supplement resources for the clinicians: http://cms.herbalgram.org/heg/volume7/files/HerbalGuide_FM.pdf. Accessed on October 23,2013

Désirée Lie. AAFP 2006 - Evidence-Based Complementary and Alternative Medicine (CAM): What Should Physicians Know? Medscape. Dec 08, 2006.

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Published

2014-11-07

How to Cite

Bindlish, MD, Shagun, and Jay H. Shubrook Jr., DO, FACOFP. “Dietary and Botanical Supplement Therapy in Diabetes”. Osteopathic Family Physician, vol. 6, no. 6, Nov. 2014, https://ofpjournal.com/index.php/ofp/article/view/355.

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Section

Review Articles
Received 2014-10-27
Accepted 2014-10-27
Published 2014-11-07